Every human t(9;11) cell line, with every accession fetched and read back: eleven lines, ten patients, and two of them are B-ALL

[
  "https://api.cellosaurus.org/search/cell-line?q=KMT2A-MLLT3 (and MLL-AF9, MLL-MLLT3), paged, filtered on the structured fusion comment and on absence of an HI line",
  "individual https://api.cellosaurus.org/cell-line/<accession>?format=txt fetches for all twelve accessions discussed"
]

[
  {
    "name": "THP-1",
    "accession": "CVCL_0006",
    "sex": "Male",
    "age": "1Y",
    "disease": "childhood acute monocytic leukemia",
    "lineage": "monocytic",
    "site": "peripheral blood",
    "co_lesions": [
      "NRAS p.Gly12Asp het",
      "TP53 p.Arg174fs*3 het"
    ],
    "depmap": "ACH-000146"
  },
  {
    "name": "MOLM-13",
    "accession": "CVCL_2119",
    "sex": "Male",
    "age": "20Y",
    "disease": "adult acute monocytic leukemia; MDS",
    "lineage": "monocytic",
    "site": "peripheral blood",
    "co_lesions": [
      "FLT3-ITD het"
    ],
    "depmap": "ACH-000362",
    "same_individual_as": "CVCL_7916"
  },
  {
    "name": "MOLM-14",
    "accession": "CVCL_7916",
    "sex": "Male",
    "age": "20Y",
    "disease": "adult AML",
    "lineage": "myeloid",
    "site": "peripheral blood",
    "co_lesions": [
      "FLT3-ITD"
    ],
    "same_individual_as": "CVCL_2119"
  },
  {
    "name": "NOMO-1",
    "accession": "CVCL_1609",
    "sex": "Female",
    "age": "31Y",
    "disease": "adult acute monocytic leukemia",
    "lineage": "monocytic",
    "site": "bone marrow",
    "co_lesions": [
      "KRAS p.Gly13Asp het",
      "TP53 p.Cys242Alafs*5 het",
      "EP300 c.730-10T>C het"
    ],
    "depmap": "ACH-000168"
  },
  {
    "name": "Mono-Mac-6",
    "accession": "CVCL_1426",
    "sex": "Male",
    "age": "64Y",
    "disease": "adult acute monocytic leukemia",
    "lineage": "monocytic",
    "site": "peripheral blood",
    "co_lesions": [
      "TP53 p.Arg273His",
      "RUNX1-ATP8A2 fusion"
    ],
    "same_individual_as": "CVCL_1425"
  },
  {
    "name": "IMS-M1",
    "accession": "CVCL_A623",
    "sex": "Male",
    "age": "33Y",
    "disease": "adult AML",
    "lineage": "myeloid",
    "site": "bone marrow"
  },
  {
    "name": "UG3",
    "accession": "CVCL_5382",
    "sex": "Female",
    "age": "26Y",
    "disease": "adult acute monocytic leukemia",
    "lineage": "monocytic",
    "site": "peripheral blood"
  },
  {
    "name": "YBT-5",
    "accession": "CVCL_YJ20",
    "sex": "Male",
    "age": "63Y",
    "disease": "adult AML",
    "lineage": "myeloid",
    "site": "bone marrow",
    "note": "established and characterised as DOT1L-inhibitor-sensitive"
  },
  {
    "name": "YCU-AML2",
    "accession": "CVCL_E7AL",
    "sex": "Male",
    "age": "5Y",
    "disease": "childhood acute monocytic leukemia",
    "lineage": "monocytic",
    "site": "peripheral blood",
    "co_lesions": [
      "KRAS p.Gly12Ala hom",
      "CDKN2A homozygous deletion",
      "CDKN2B homozygous deletion",
      "MECOM overexpression"
    ],
    "fusion_structure": "KMT2A intron 8 fused to MLLT3 intron 4"
  },
  {
    "name": "KOPB-26",
    "accession": "CVCL_7972",
    "sex": "Female",
    "age": "1Y1M",
    "disease": "childhood B-ALL with t(v;11q23.3)",
    "lineage": "B-lymphoid",
    "site": "peripheral blood",
    "co_lesions": [
      "NSD2 p.Glu1099Lys het",
      "TP53 p.Pro278Leu",
      "TP53 p.Arg283fs"
    ]
  },
  {
    "name": "YACL95",
    "accession": "CVCL_D4A3",
    "sex": "unspecified",
    "age": "<1Y",
    "disease": "childhood B-ALL with t(v;11q23.3)",
    "lineage": "B-lymphoid"
  }
]

[
  "YCU-AML2"
]

[
  "engineered knockout and reporter derivatives of THP-1 and MOLM-13 (several hundred records, excluded by requiring no HI hierarchy line)",
  "MLL/AF9 Cas9 (CVCL_C8ZF), a mouse line whose fusion is a transgene"
]

{
  "entry": "ana-kmt2a-r-line-panel-monocytic-audit",
  "field": "control_arm_disqualifications / Mono-Mac-1 'retained as the only clean comparator'",
  "issue": "Mono-Mac-1 (CVCL_1425) is autologous with Mono-Mac-6 (CVCL_1426), which Cellosaurus annotates KMT2A-MLLT3 citing PMID 7833491; Mono-Mac-1's fusion-negative status is an absence of annotation, not an assay",
  "suggested_text": "the only comparator not positively disqualified; its KMT2A fusion status is unannotated rather than negative, in a line autologous with the KMT2A::MLLT3-positive Mono-Mac-6",
  "source": "Cellosaurus CVCL_1425 and CVCL_1426 fetched 2026-09-20; PMID 7833491",
  "read": "records read in full; PMID 7833491 read as title and curation only"
}

{
  "line": "SDEY-AML1",
  "pmid": "41656387",
  "cellosaurus": "no accession as of 2026-09-20",
  "effect": "panel is 11 lines by Cellosaurus and at least 12 by the literature",
  "title": "A novel human acute myeloid leukemia cell line SDEY-AML1 with KMT2A: MLLT3, IKZF1: EVX1 fusions exhibits high tumorigenicity in NSG mice.",
  "authors": "Yang C, Zhang W, Wu Y, et al.",
  "venue": "Sci Rep",
  "year": 2026,
  "title_provenance": "Title/authors/venue backfilled from PubMed esummary on 2026-09-20 because this citation stored a bare PMID with no title, which made it unscoreable by verify-citations.py. BACKFILLING IS NOT VERIFICATION: it confirms the PMID resolves to a real paper, not that this is the right paper for the claim. That still requires reading."
}