The H3K79me2 eviction gradient is not a ratio of sums dominated by a few bins: the MEDIAN per-bin log2 share ratio is itself monotone at Spearman -1.000, the fraction of bins individually below 1 falls 89.3% to 24.7%, the bootstrap span interval is [-0.651, -0.545], and no single bin moves the span by more than 0.0057

[
  "GSM8123438/439/440 NT",
  "GSM8123435/436/437 PCGF1-KO C1"
]

{
  "K79_NT_VTP": {
    "R_by_quartile": [
      0.586,
      0.8188,
      0.928,
      1.1865
    ],
    "span_Q1_minus_Q4": -0.6005,
    "median_per_bin_log2_ratio_by_quartile": [
      -0.7213,
      -0.168,
      -0.0158,
      0.2673
    ],
    "median_per_bin_log2_spearman_vs_depth": -1,
    "fraction_of_bins_below_1_by_quartile": [
      0.8929,
      0.6503,
      0.5114,
      0.2467
    ],
    "n_bins_with_signal_in_both_tracks": [
      308,
      306,
      307,
      304
    ],
    "largest_single_bin_share_of_quartile_DMSO": [
      0.0066,
      0.0084,
      0.011,
      0.0111
    ],
    "bootstrap_R_ci95_by_quartile": [
      [
        0.5506,
        0.6207
      ],
      [
        0.7789,
        0.8567
      ],
      [
        0.885,
        0.9734
      ],
      [
        1.145,
        1.2272
      ]
    ],
    "bootstrap_span_mean": -0.6001,
    "bootstrap_span_ci95": [
      -0.651,
      -0.5446
    ],
    "bootstrap_fraction_of_resamples_with_span_of_observed_sign": 1,
    "leave_one_bin_out_worst_change_in_span": 0.0057
  },
  "K79_NT_SGC": {
    "R_by_quartile": [
      0.1396,
      0.1453,
      0.1452,
      0.136
    ],
    "span_Q1_minus_Q4": 0.0036,
    "median_per_bin_log2_ratio_by_quartile": [
      -2.8447,
      -2.7107,
      -2.6805,
      -2.7389
    ],
    "median_per_bin_log2_spearman_vs_depth": -0.4,
    "fraction_of_bins_below_1_by_quartile": [
      1,
      0.9837,
      0.9935,
      0.9477
    ],
    "n_bins_with_signal_in_both_tracks": [
      308,
      306,
      307,
      306
    ],
    "largest_single_bin_share_of_quartile_DMSO": [
      0.0066,
      0.0084,
      0.011,
      0.0111
    ],
    "bootstrap_R_ci95_by_quartile": [
      [
        0.1342,
        0.1454
      ],
      [
        0.1391,
        0.1517
      ],
      [
        0.1377,
        0.1529
      ],
      [
        0.1267,
        0.1461
      ]
    ],
    "bootstrap_span_mean": 0.0034,
    "bootstrap_span_ci95": [
      -0.0078,
      0.0138
    ],
    "bootstrap_fraction_of_resamples_with_span_of_observed_sign": 0.7305,
    "leave_one_bin_out_worst_change_in_span": 0.0014
  },
  "K79_C1_VTP": {
    "R_by_quartile": [
      0.6123,
      0.7955,
      0.8928,
      1.0464
    ],
    "span_Q1_minus_Q4": -0.4341,
    "median_per_bin_log2_ratio_by_quartile": [
      -0.633,
      -0.2363,
      -0.0837,
      0.0713
    ],
    "median_per_bin_log2_spearman_vs_depth": -1,
    "fraction_of_bins_below_1_by_quartile": [
      0.8669,
      0.6984,
      0.5733,
      0.4169
    ],
    "n_bins_with_signal_in_both_tracks": [
      308,
      305,
      307,
      307
    ],
    "largest_single_bin_share_of_quartile_DMSO": [
      0.0061,
      0.008,
      0.0093,
      0.0099
    ],
    "bootstrap_R_ci95_by_quartile": [
      [
        0.5759,
        0.6474
      ],
      [
        0.7615,
        0.8327
      ],
      [
        0.8556,
        0.9295
      ],
      [
        1.0158,
        1.0767
      ]
    ],
    "bootstrap_span_mean": -0.4346,
    "bootstrap_span_ci95": [
      -0.4814,
      -0.3897
    ],
    "bootstrap_fraction_of_resamples_with_span_of_observed_sign": 1,
    "leave_one_bin_out_worst_change_in_span": 0.0044
  },
  "K79_C1_SGC": {
    "R_by_quartile": [
      0.1334,
      0.1325,
      0.1349,
      0.1225
    ],
    "span_Q1_minus_Q4": 0.011,
    "median_per_bin_log2_ratio_by_quartile": [
      -2.8671,
      -2.8406,
      -2.8226,
      -2.8885
    ],
    "median_per_bin_log2_spearman_vs_depth": 0.2,
    "fraction_of_bins_below_1_by_quartile": [
      1,
      0.9902,
      0.9837,
      0.9316
    ],
    "n_bins_with_signal_in_both_tracks": [
      308,
      305,
      307,
      307
    ],
    "largest_single_bin_share_of_quartile_DMSO": [
      0.0061,
      0.008,
      0.0093,
      0.0099
    ],
    "bootstrap_R_ci95_by_quartile": [
      [
        0.1288,
        0.1383
      ],
      [
        0.1272,
        0.138
      ],
      [
        0.1281,
        0.1423
      ],
      [
        0.1148,
        0.1307
      ]
    ],
    "bootstrap_span_mean": 0.0109,
    "bootstrap_span_ci95": [
      0.0018,
      0.0203
    ],
    "bootstrap_fraction_of_resamples_with_span_of_observed_sign": 0.991,
    "leave_one_bin_out_worst_change_in_span": 0.0008
  }
}