Re-bound at full text: 100 records pair an MLLT1 alias with reciprocal-fusion language and 8 with spliced-fusion language, and none stratifies a KMT2A::MLLT1 outcome, transcriptome or drug response by reciprocal or spliced status
also called Q115 MLLT1 reciprocal re-bound
Some patients carry the mirror-image copy of the fusion gene as well as the main one, and nobody has ever asked whether that changes anything for this particular partner. Searching whole papers confirms it.
The same thing, for a scientist
Re-run at full text with a six-alias MLLT1 group: `x (reciprocal fusion OR reciprocal transcript OR reciprocal translocation)` returns **100**, `x (spliced fusion OR alternatively spliced fusion)` returns **8**, and the same-shape positive control `MLL-AF4 x reciprocal fusion` returns **48** [E1]. The 50 read of the 100 and all 8 of the spliced set were title-screened. **The recall is recombinome censuses (2013, 2017, 2023), fusion-detection method papers, CRISPR translocation models and reviews. Not one stratifies an outcome, transcriptome or drug response by reciprocal or spliced status for this partner.** The spliced set contains the single 2007-lineage observation the entry already cites plus a *BMC Cancer* 2010 report of a spliced MLL-CT45A2 fusion - a different partner [E1]. **The absence survives.** The nearest miss is **PMID 42001795** (*Neoplasia* 2026), *Characterizing the impact of MLL fusion variants and fusion partners on leukemia plasticity using a human CRISPR model* - fusion **variants** is the entry's own vocabulary, the system is human, and it was not opened [E2].
| script | none - Europe PMC BODY: queries, 2026-09-22 |
|---|---|
| status | run |
| verdict | SURVIVES at full text |
| entry re bounded | absence-no-kmt2a-mllt1-analysis-stratified-by-reciprocal-or-spliced-status |
| absence class | measured-not-reported |
| absence class basis | UNCHANGED. The recombinome censuses that dominate the hit list DO record reciprocal-product status per case, so the variable exists in published datasets and has never been crossed with outcome for this partner - which is what measured-not-reported means. No new accession was identified. |
queries — the numbers behind the chart
[
{
"q": "MLLT1 alias group AND reciprocal-fusion language",
"hits": 100,
"read": 50,
"on_topic": 0,
"proceedings": 0
},
{
"q": "MLLT1 alias group AND spliced-fusion language",
"hits": 8,
"read": 8,
"on_topic": 0,
"proceedings": 2
},
{
"q": "MLL-AF4 AND \"reciprocal fusion\"",
"hits": 48,
"role": "positive control, identical shape"
}
]aliases searched
[ "MLLT1", "MLL-ENL", "ENL-MLL", "KMT2A::MLLT1", "LTG19", "YEATS1" ]
aliases excluded
[
{
"alias": "ENL",
"reason": "contaminated free-text token, consistent with the entry under test"
}
]nearest record
{
"pmid": "42001795",
"status": "NOT OPENED"
}- Does PMID 42001795 compare reciprocal-product status among its MLL fusion variants, and does its panel include t(11;19)? One read could overturn this entry.
- The recombinome censuses record reciprocal status per case. Could their supplementary tables be crossed with the outcome data in the pooled paediatric prognostic study the entry already cites? That would be a desk job rather than a new cohort.
- Half the 100-record reciprocal set is unread and relevance ranking disfavours single-partner analyses. Reading the tail is the unfinished half.
- E1strong confidence 4 of 5: Replicated in peer-reviewed work by more than one group.database
At full text the MLLT1 alias group returns 100 records with reciprocal-fusion language and 8 with spliced-fusion language, with a same-shape positive control of 48 for MLL-AF4 x reciprocal fusion, and no record among the 58 screened stratifies a KMT2A::MLLT1 outcome by reciprocal or spliced status.
Europe PMC RESTful search, BODY: MLLT1 aliases x reciprocal/spliced fusion language, 2026-09-22 · Europe PMC 2026What this evidence cannot show
Europe PMC BODY: reaches only the 12,362,145 full texts the index holds, so a paywalled paper remains invisible. A congress abstract book is one document holding thousands of unrelated abstracts and matches almost any conjunction; across this beat's 18 fully-read intersections 83 of 321 records (25.9%, range 0-50%) are proceedings. Screening was at TITLE level unless a paper is listed as opened. 50 of the 100 reciprocal hits were read; 50 were not. Zero proceedings in the 50 read. The alias group deliberately excludes bare ENL as a contaminated token, consistent with the entry under test, so a paper writing only ENL is not reached.
Evidence that argues against this (1)
- Half the reciprocal set is unread and the set is ordered by relevance, which favours recombinome censuses that name every partner. A single-partner outcome analysis would rank low. The screened zero covers 58 of 108 records across the two queries. Europe PMC 2026
- E2moderate confidence 3 of 5: One strong study, or several smaller consistent ones.paper
The nearest unread record is a 2026 Neoplasia study characterising the impact of MLL fusion variants and fusion partners on leukaemia plasticity in a human CRISPR model.
Characterizing the impact of MLL fusion variants and fusion partners on leukemia plasticity using a human CRISPR model. · Neoplasia 2026What this evidence cannot show
TITLE-CHECKED ONLY, taken from the full Europe PMC record. 'Fusion variants' in a CRISPR-model context most likely means different breakpoints or different partners rather than reciprocal-product status, but the two cannot be told apart from the title.
Evidence that argues against this (1)
- A CRISPR model that engineers translocations can produce reciprocal products by construction, and a paper comparing 'fusion variants' in such a model is the single most likely place a reciprocal-versus-non-reciprocal comparison exists for any partner. If it includes t(11;19), the entry falls. Neoplasia 2026
SURVIVES at full text: 100 + 8 records, 58 screened, 0 stratify by reciprocal or spliced status
- related to →KMT2A::MLLT1 (MLL-ENL), t(11;19)(q23;p13.3)
no reciprocal- or spliced-stratified outcome analysis exists for this fusion at full text