Re-bound at full text: no study of MLLT1/ENL function in cerebellum or developing brain exists, and 10 of the 22 full-text hits are congress abstract books - the weakest-bounded absence in the corpus is now the best-bounded of the four ENL ones
also called Q115 ENL brain re-bound
ENL is the drug target most abundant in the fast-growing part of an infant's brain, and nobody has studied what it does there. Searching the whole text of twelve million papers instead of just their summaries finds nothing, and nearly half of what it does find are conference programmes.
The same thing, for a scientist
`absence-enl-function-in-developing-brain` was the cycle-65 census's nominated weakest bound: two queries, no MeSH, no full alias set, no full text, and no `confidence_overall` or `status` field of its own. **Its first open question asked for exactly this re-run and it is now done.** Full text, alias group `MLLT1 OR YEATS1 OR LTG19`: `x (cerebellum OR cerebellar)` returns **22**, `MLLT1 x cerebellum` **16**, `MLLT1 x (neural stem cell OR neurodevelopment OR neurodevelopmental OR Purkinje)` **30**, `MLLT1 x "brain development"` **11** [E1]. Operands pass (`MLLT1` 752, `cerebellum` 192,730) and the same-shape positive control `MEN1 x cerebellum` returns **161**, so the template finds brain work on a comparable target [E2]. **Every title in all four sets was read and none is a study of ENL in brain.** The recall is cattle dystocia, an Alzheimer in-silico screen, a consanguineous-family exome series, cytoskeletal and psychiatric reviews, two single-cell atlas papers in which MLLT1 is one row of a biomarker table, and **10 of the 22 cerebellum hits are congress abstract books** [E1].
The one class of hit that is not noise
Two records are single-cell atlas papers in which MLLT1 appears as a member of a computed gene list: PMID 38739758 (Brief Bioinform 2024, early brain development biomarkers and their regulatory footprints in human embryonic single-cell data) and PMID 38580401 (Genome Res 2024, pooled TF induction with scRNA-seq). Neither studies ENL; both are the shape of thing the entry's second open question asks for - a developmental expression atlas rather than adult post-mortem tissue - and both were found by this search rather than by the atlas route.
Also present and closer to biology than the rest: PMID 35279775 (Cell Mol Life Sci 2022, Multifaceted roles of YEATS domain-containing proteins and novel links to neurological diseases), a review that appears in three of the four intersections. If any paper summarises what is known about YEATS proteins in the nervous system it is that one, and it was not opened.
What is still not bounded
The entry's remaining open questions are untouched by this re-bound and two of them name instruments this beat did not reach: OMIM, ClinGen and DECIPHER for a germline MLLT1 phenotype, and BrainSpan or the Human Developmental Cell Atlas for a developmental expression trajectory. A germline loss-of-function phenotype would sit in those registries under a condition name and would be invisible to any literature query, [tiab] or full text. That is the same instrument-mismatch shape the census found for the antibody and PTM entries, and it is unresolved here.
| script | none - Europe PMC BODY: queries, 2026-09-22 |
|---|---|
| status | run |
| verdict | SURVIVES at full text; the entry's own first open question is ANSWERED |
| entry re bounded | absence-enl-function-in-developing-brain |
| instrument before | two abstract-level queries, no alias set, no full text - the census's nominated weakest bound |
| instrument after | four full-text intersections over 12,362,145 full texts, alias group of three, all titles read |
| absence class | measured-not-analysed |
| absence class basis | UNCHANGED from the 2026-09-21 assignment (GEO holds 151 human developing-brain/cerebellum single-cell datasets including GSE327101). This re-bound changes the LITERATURE instrument from abstract-level to full text; it does not change the archive position, which already carried an accession. |
queries — the numbers behind the chart
[
{
"q": "(MLLT1 OR YEATS1 OR LTG19) AND (cerebellum OR cerebellar)",
"hits": 22,
"on_topic": 0,
"proceedings": 10
},
{
"q": "MLLT1 AND cerebellum",
"hits": 16,
"on_topic": 0,
"proceedings": 7
},
{
"q": "MLLT1 AND (neural stem cell OR neurodevelopment OR neurodevelopmental OR Purkinje)",
"hits": 30,
"on_topic": 0,
"proceedings": 6
},
{
"q": "MLLT1 AND \"brain development\"",
"hits": 11,
"on_topic": 0,
"proceedings": 2
},
{
"q": "MLLT1",
"hits": 752,
"role": "operand control"
},
{
"q": "cerebellum",
"hits": 192730,
"role": "operand control"
},
{
"q": "MEN1 AND cerebellum",
"hits": 161,
"role": "positive control, identical shape"
}
]aliases searched
[ "MLLT1", "YEATS1", "LTG19" ]
aliases excluded
[
{
"alias": "ENL",
"reason": "contaminated free-text token; this is the largest gap in the bound and is stated as such"
}
]nearest records
[
{
"pmid": "35279775",
"title": "Multifaceted roles of YEATS domain-containing proteins and novel links to neurological diseases.",
"venue": "Cell Mol Life Sci",
"year": 2022,
"status": "NOT OPENED - appears in three of the four intersections"
},
{
"pmid": "38739758",
"title": "Single-cell RNA-seq data analysis reveals functionally relevant biomarkers of early brain development and their regulatory footprints in human embryonic data",
"venue": "Brief Bioinform",
"year": 2024,
"status": "NOT OPENED - MLLT1 appears as a row in a computed biomarker list"
}
]instruments still not reached
[ "OMIM", "ClinGen", "DECIPHER", "BrainSpan", "Human Developmental Cell Atlas" ]
- The cerebellum grows fastest in the first two years, which is exactly when an infant with this disease is treated. An ENL-directed agent would be dosed into the organ where the target is most abundant and least studied, and the absence of a published phenotype is not reassurance - it is the absence of anyone having looked.
- Does BODY:"ENL" AND BODY:"cerebellum" return anything? Bare ENL was excluded as contaminated and it is the one spelling a developmental neuroscientist would use. This is the cheapest refutation of this re-bound.
- Does PMID 35279775 review any nervous-system function of the YEATS family, and if so does it cite a primary ENL brain paper this search missed?
- Is there an MLLT1 germline loss-of-function phenotype in OMIM, ClinGen or DECIPHER? The entry names 11 gnomAD loss-of-function carriers who have never been phenotyped, and no literature instrument of any depth can reach a registry condition name.
- E1strong confidence 4 of 5: Replicated in peer-reviewed work by more than one group.database
Europe PMC full-text intersections of the MLLT1 alias group with cerebellar and neurodevelopmental terms return 22, 16, 30 and 11 records, every title read, none a study of ENL function in brain, and 10 of the 22 cerebellum hits are congress abstract books.
Europe PMC RESTful search, BODY: MLLT1 alias group x cerebellum/neurodevelopment, 2026-09-22 · Europe PMC 2026What this evidence cannot show
Europe PMC BODY: reaches only the 12,362,145 full texts the index holds, so a paywalled paper is still invisible; and a congress abstract book is indexed as one document containing thousands of unrelated abstracts, so a fraction of every hit list here is proceedings (measured across this beat's 18 fully-read intersections: 83 of 321 records, 25.9%, range 0-50%). Screening was at TITLE level unless a paper is listed as opened. The alias group is MLLT1, YEATS1 and LTG19; bare ENL was deliberately excluded as a contaminated token, consistent with the treatment of it elsewhere in this corpus, which means a paper writing only 'ENL' in its body is not reached. That is a real gap in this bound and it is the direction that would find something.
Evidence that argues against this (1)
- Excluding bare ENL is the single largest hole in this re-bound. A developmental-neuroscience paper would plausibly write ENL without ever writing MLLT1, because the gene-symbol convention is a haematology habit. Running BODY:"ENL" AND BODY:"cerebellum" and title-screening the result is the obvious refutation route and was not run. Europe PMC 2026
- E2established confidence 5 of 5: Multiple independent lines of evidence; treated as settled in the field.database
The search template demonstrably finds brain work on a comparable target: BODY:"MEN1" AND BODY:"cerebellum" returns 161 records, against operands of 752 for MLLT1 and 192,730 for cerebellum.
What this evidence cannot show
MEN1 is a poor comparator in one respect - it is a hereditary tumour syndrome gene with a large clinical literature that mentions many anatomical sites - so 161 overstates how much genuine cerebellar biology a well-studied chromatin gene attracts. It is a control on the TEMPLATE, not a benchmark for the expected count.
Evidence that argues against this (1)
- A control that returns 161 for a gene with a neuroendocrine tumour literature does not establish that 22 is low for a chromatin reader. The honest comparison would be a matched chromatin gene of similar total literature size; that was not run, so this beat has shown the instrument works and has not shown that ENL is anomalously unstudied in brain relative to its peers. Europe PMC 2026
SURVIVES at full text across four intersections with all titles read; answers the entry's own first open question
no full-text record of ENL function in cerebellum or developing brain, the tissue of its highest expression