No fusion oncoprotein in any family has a published replication-protein-A measurement: 23 queries across five fusion families and four spelling variants each, every querytranslation read back, zero records - so the PI's analogy dimension for RPA has no comparator at all, and the index fusion's single locus-level result is the entire field

{
  "tried_against_all_five_families": [
    "\"replication protein A\""
  ],
  "tried_against_some_families": [
    "RPA2 (NUP98, Ewing sarcoma)"
  ],
  "not_tried_against_any_family": [
    "RPA1",
    "RPA3",
    "RPA32",
    "RPA34",
    "RFA2",
    "REPA1",
    "REPA2",
    "REPA3",
    "HSSB",
    "RP-A",
    "RF-A",
    "\"RPA complex\""
  ],
  "why_this_matters": "The one KMT2A-locus paper is reachable ONLY by the complex name and the menin literature ONLY by the subunit symbol. A one-sided name list is demonstrably capable of missing an entire literature, and this sweep is one-sided."
}

{
  "tried": [
    "\"EWS-FLI1\"",
    "\"EWSR1-FLI1\"",
    "\"EWS/FLI\"",
    "\"EWS-FLI\"",
    "\"Ewing sarcoma\"",
    "\"BCR-ABL\"",
    "\"BCR-ABL1\"",
    "\"BCR/ABL\"",
    "\"PML-RARA\"",
    "\"PML/RARA\"",
    "\"PML-RAR\"",
    "\"ETV6-RUNX1\"",
    "\"ETV6/RUNX1\"",
    "\"TEL-AML1\"",
    "NUP98",
    "\"fusion oncoprotein\"",
    "\"fusion protein\""
  ],
  "not_tried": [
    "CBFB::MYH11",
    "RUNX1::RUNX1T1 / AML1-ETO",
    "TCF3::PBX1",
    "TCF3::HLF",
    "CBFA2T3::GLIS2",
    "DUX4::IGH",
    "NPM1::ALK",
    "ETV6::NTRK3",
    "every KMT2A partner other than AF4",
    "the specific NUP98 partner fusions (NUP98-NSD1, NUP98-KDM5A, NUP98-HOXA9)"
  ]
}

[
  {
    "q": "\"EWS-FLI1\"[tiab] AND \"replication protein A\"[tiab]",
    "count": 0,
    "genuine_zero": true
  },
  {
    "q": "\"EWSR1-FLI1\"[tiab] AND \"replication protein A\"[tiab]",
    "count": 0,
    "genuine_zero": true
  },
  {
    "q": "\"EWS/FLI\"[tiab] AND \"replication protein A\"[tiab]",
    "count": 0,
    "genuine_zero": true
  },
  {
    "q": "\"EWS-FLI\"[tiab] AND \"replication protein A\"[tiab]",
    "count": 0,
    "genuine_zero": true
  },
  {
    "q": "\"Ewing sarcoma\"[tiab] AND \"replication protein A\"[tiab]",
    "count": 0,
    "genuine_zero": true
  },
  {
    "q": "RPA32[tiab] AND \"EWS-FLI1\"[tiab]",
    "count": 0,
    "genuine_zero": true
  },
  {
    "q": "RPA[tiab] AND \"EWS-FLI1\"[tiab]",
    "count": 0,
    "genuine_zero": true
  },
  {
    "q": "RPA2[tiab] AND \"Ewing sarcoma\"[tiab]",
    "count": 1,
    "ids": [
      "31213834"
    ],
    "on_topic": 0,
    "note": "differential-expression hub-gene screen, not mechanism"
  },
  {
    "q": "\"BCR-ABL\"[tiab] AND \"replication protein A\"[tiab]",
    "count": 0,
    "genuine_zero": true
  },
  {
    "q": "\"BCR-ABL1\"[tiab] AND \"replication protein A\"[tiab]",
    "count": 0,
    "genuine_zero": true
  },
  {
    "q": "\"BCR/ABL\"[tiab] AND \"replication protein A\"[tiab]",
    "count": 0,
    "genuine_zero": true
  },
  {
    "q": "RPA32[tiab] AND \"BCR-ABL\"[tiab]",
    "count": 0,
    "genuine_zero": true
  },
  {
    "q": "\"PML-RARA\"[tiab] AND \"replication protein A\"[tiab]",
    "count": 0,
    "genuine_zero": true
  },
  {
    "q": "\"PML/RARA\"[tiab] AND \"replication protein A\"[tiab]",
    "count": 0,
    "genuine_zero": true
  },
  {
    "q": "\"PML-RAR\"[tiab] AND \"replication protein A\"[tiab]",
    "count": 0,
    "genuine_zero": true
  },
  {
    "q": "\"ETV6-RUNX1\"[tiab] AND \"replication protein A\"[tiab]",
    "count": 0,
    "genuine_zero": true
  },
  {
    "q": "\"ETV6/RUNX1\"[tiab] AND \"replication protein A\"[tiab]",
    "count": 0,
    "genuine_zero": true
  },
  {
    "q": "\"TEL-AML1\"[tiab] AND \"replication protein A\"[tiab]",
    "count": 0,
    "genuine_zero": true
  },
  {
    "q": "NUP98[tiab] AND \"replication protein A\"[tiab]",
    "count": 0,
    "genuine_zero": true
  },
  {
    "q": "NUP98[tiab] AND RPA2[tiab]",
    "count": 0,
    "genuine_zero": true
  },
  {
    "q": "\"fusion oncoprotein\"[tiab] AND \"replication protein A\"[tiab]",
    "count": 0,
    "genuine_zero": true
  },
  {
    "q": "fusion[tiab] AND oncoprotein[tiab] AND \"replication protein A\"[tiab]",
    "count": 0,
    "genuine_zero": true
  },
  {
    "q": "\"fusion protein\"[tiab] AND \"replication protein A\"[tiab]",
    "count": 9,
    "on_topic": 0,
    "note": "all nine are recombinant tagged constructs; see E2"
  }
]

{
  "\"replication protein A\"[tiab]": 1569,
  "\"BCR-ABL\"[tiab]": 10221,
  "NUP98[tiab]": 863,
  "\"PML-RARA\"[tiab]": 841,
  "\"EWS-FLI1\"[tiab]": 650,
  "\"ETV6-RUNX1\"[tiab]": 603,
  "note": "every operand returns hundreds to thousands of records through the identical query shape, so the conjunction zeros are about the conjunctions and not about the instrument (rule 67)"
}

[
  "A full-text or figure-level search rather than a title/abstract search. RPA2 foci and phospho-RPA2 are standard readouts and would be in figures - Europe PMC full-text search is the cheapest route and was not used.",
  "A GEO or PRIDE sweep for RPA occupancy or RPA-containing proteomics in any of the five families. Not run.",
  "The breakpoint-level version of the question, which is the better analogy for the one result that exists: does RPA load at the RUNX1 or PML breakpoint after etoposide, as it does at the KMT2A BCR? Not queried in any form."
]

[
  {
    "quantity": "count",
    "subject": "records naming replication protein A with any of five fusion-oncoprotein families in title or abstract",
    "value": 0,
    "units": "records",
    "n": 22,
    "universe": "22 conjunction queries across EWSR1::FLI1, BCR::ABL1, PML::RARA, ETV6::RUNX1 and NUP98 with 4 spellings each on the fusion side, PubMed title/abstract, 2026-09-24, every querytranslation read back",
    "null": 1569,
    "note": "null is the count for \"replication protein A\"[tiab] alone. The fusion-side operands range from 603 to 10,221 records, so the zero is not a small-literature artefact on either side."
  },
  {
    "quantity": "count",
    "subject": "on-topic hits among the 9 records matching \"fusion protein\" AND \"replication protein A\"",
    "value": 0,
    "units": "records",
    "n": 9,
    "universe": "all nine titles retrieved by esummary and read, 2026-09-24",
    "null": null,
    "note": "all nine use 'fusion protein' for a recombinant tagged construct. The token is contaminated for this project's purposes and was NOT added to the collision registry by this beat."
  },
  {
    "quantity": "count",
    "subject": "published RPA measurements in any fusion-oncoprotein family, of any design",
    "value": 1,
    "units": "measurements",
    "n": 6,
    "universe": "the six fusion families considered by this beat (KMT2A plus the five above)",
    "null": 0,
    "note": "the one is PMID 21048951, a locus-occupancy measurement in cells containing NO fusion. Counting it as a cross-family comparator is generous and the entry says so."
  }
]